October 29, 2021
Today is World Psoriasis Day. It is a great opportunity to share a review of the literature on this chronic skin pathology.
This review, written by our medical writing team, describes the various pathophysiological mechanisms involved in psoriasis, and focuses on the changes observed in the so-called non-lesional skin of patients with psoriasis. Despite its normal appearance, this non-lesional psoriatic skin represents an intermediate state between healthy and lesional skin, with alterations that can be observed at several levels: the skin barrier, keratinocytes, innate and adaptive immune responses, microbiota and neurogenic tissue innervation.
These alterations are mostly located in the epidermis and are therefore readily accessible to topical treatments, which could prevent the recurrence/spread of this chronic disease.